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High sensitivity and interindividual variability in the response of the human circadian system to evening light
Phillips, Vidafar, Burns, McGlashan, Anderson, Rajaratnam, et al. · 2019 · Proceedings of the National Academy of Sciences 116(24):12019–12024
What this work gives Aellic
Within-subject laboratory dose-response study, 55 adults aged 18–30, 10 to 2,000 lux for 5 h in the evening: group ED50 for melatonin suppression was 24.6 lux, with individual values from 6 to 350 lux; 10, 30 and 50 lux delayed melatonin onset by 22, 77 and 109 min. Graded observational only because the registry has no value for a non-randomised experiment.
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